Pakistan's nuclear program is based primarily on highly enriched uranium (HEU), which is produced at the A. Q. Khan research laboratory at Kahuta, a gas centrifuge uranium enrichment facility. The Kahuta facility has been in operation since the early 1980s. By the early 1990s, Kahuta had an estimated 3,000 centrifuges in operation, and Pakistan continued its pursuit of expanded uranium enrichment capabilities.
In the 1990s Pakistan began to pursue plutonium production capabilities. With Chinese assistance, Pakistan built the 40 MWt (megawatt thermal) Khusab research reactor at Joharabad, and in April 1998, Pakistan announced that the reactor was operational. According to public statements made by US officials, this unsafeguarded heavy water reactor generates an estimated 8-10 kilotons of weapons grade plutonium per year, which is enough for one to two nuclear weapons. The reactor could also produce tritium if it were loaded with lithium-6. According to J. Cirincione of Carnegie, Khusab's plutonium production capacity could allow Pakistan to develop lighter nuclear warheads that would be easier to deliver with a ballistic missile.
Plutonium separation reportedly takes place at the New Labs reprocessing plant next to Pakistan's Institute of Nuclear Science and Technology (Pinstech) in Rawalpindi and at the larger Chasma nuclear power plant, neither of which are subject to IAEA inspection.
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